cyclic AMP Regulation and Its Command in the Pacemaker Channel HCN4
نویسندگان
چکیده
منابع مشابه
Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP.
Important targets for cAMP signalling in the heart are hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels that underlie the depolarizing 'pacemaker' current, I(f). We studied the role of I(f) in mice, in which binding of cAMP to HCN4 channels was abolished by a single amino-acid exchange (R669Q). Homozygous HCN4(R669Q/R669Q) mice die during embryonic development. Prior to E1...
متن کاملMechanisms of Cyclic Amp-dependent Modulation in Pacemaker Channels
Pacemaker (HCN) channels are hyperpolarization-activated and their activity is enhanced by cyclic AMP (CAMP), but whether CAMP-gating is coupled to voltage-gating remains unresolved. With long hyperpolarizations, HCN channels form a secondary open state after the initial opening; this briefly sustains the activation of open channels after a return to a resting voltage. CAMP effects on the forma...
متن کاملthe survey of the virtual higher education in iran and the ways of its development and improvement
این پژوهش با هدف "بررسی وضعیت موجود آموزش عالی مجازی در ایران و راههای توسعه و ارتقای آن " و با روش توصیفی-تحلیلی و پیمایشی صورت پذیرفته است. بررسی اسنادو مدارک موجود در زمینه آموزش مجازی نشان داد تعداد دانشجویان و مقاطع تحصیلی و رشته محل های دوره های الکترونیکی چندان مطلوب نبوده و از نظر کیفی نیز وضعیت شاخص خدمات آموزشی اساتید و وضعیت شبکه اینترنت در محیط آموزش مجازی نامطلوب است.
Activity-Dependent Regulation of HCN Pacemaker Channels by Cyclic AMP Signaling through Dynamic Allosteric Coupling
Signal transduction in neurons is a dynamic process, generally thought to be driven by transient changes in the concentration of second messengers. Here we describe a novel regulatory mechanism in which the dynamics of signaling through cyclic AMP are mediated by activity-dependent changes in the affinity of the hyperpolarization-activated, cation nonselective (HCN) channels for cAMP, rather th...
متن کاملNeural regulation of cyclic AMP, cyclic AMP-dependent protein kinase, and phosphorylase in bullfrog ventricular myocardium.
The roles of cyclic AMP and cyclic AMP-dependent protein kinase in the contractile and metabolic responses to neural stimulation were studied in the bullfrog heart perfused in situ. The interaction of parasympathetic and sympathetic nerves in the regulation of myocardial cyclic AMP, cyclic AMP-dependent protein kinase, and phosphorylase also was studied. Stimulation of the left vagosympathetic ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2020
ISSN: 1664-042X
DOI: 10.3389/fphys.2020.00771